Yet another high-profile retail casualty is looming on Fifth Avenue.

The Versace flagship store at 647 Fifth Ave. is being offered for a five-year sublease by James Downey and Eric Le Goff of Cushman & Wakefield, The Post has learned.

It’s a time of change for Italian fashion house Gianni Versace, which is being purchased by Michael Kors for $2.2 billion. Meanwhile, Kors’ parent company, which also owns Jimmy Choo, is changing its name to Capri Holdings. The Versace deal is expected to close by year-end.

At the time the deal was announced in September, Michael Kors said it planned to add 100 Versace stores, for a total of 300, and mute some of its more vibrant patterns. A Kors spokeswoman said that, until closing, it had no additional information about the relocation of Versace’s Manhattan flagship store.

An industry source says Versace wants to move “farther uptown” but could not get out of its lease.

Neither the Cushman & Wakefield nor the Versace spokesmen responded to requests for comment prior to press time.

The townhouse, which sits on the east side of the avenue between East 51st and 52nd streets, is a separate building but part of the Olympic Tower retail holdings. The 20-year-old store is challenged by a multilevel space with no fewer than six stories plus two below ground.

On the plus side, it includes a dramatic elliptical marble staircase and a private terrace overlooking Fifth Avenue. The lease on the stunning, 25,020-square-foot former Emily Vanderbilt Sloane mansion ends on Dec. 30, 2023.

Public documents show a city-approved signage plaque that costs $300 per year through June 30, 2022, so someone will have to renew it. (Bizarrely, the first line of that document includes a typo, calling the item a “plague.”)

“Plague” seems about right when considering the increasing number of vacant storefronts caused by various business reasons.

As The Post’s Steve Cuozzo first reported on Wednesday, The Gap closed its store at 680 Fifth Ave., despite that it wasn’t on the company’s list of store closings.

But the building owner has been offering this 33,800-square-foot multifloor store on the corner of West 55th Street with an availability of March. That listing is through Laura Pomerantz at Cushman & Wakefield.

At the same time, CoStar shows Frank Doyle at JLL is offering its second and third floors for office use.

These retail locations join the soon-to-be-vacant 55,980-square-foot Henri Bendel store at 712 Fifth Ave. soon to be offered by Richard Hodos of CBRE.

Across the street, the former Ralph Lauren store at Coca-Cola-owned 711 Fifth Ave. is being marketed by Gene Spiegelman at Ripco Real Estate and Cushman & Wakefield, his former employer.

But any sublease of the Ralph Lauren space is now being complicated by the building being offered for sale through Douglas Harmon and Adam Spies, also at C&W.

The brokers mentioned above weren’t available for comment on any of the offerings.

Others say their store tenants are leery of signing a deal without knowing who will be the next building owner. Yet for Coke, the building will sell better with the high-income, near-top-of-the-market lease guaranteed by Ralph Lauren’s credit.

The high-rent vacancies on Fifth Avenue and fairness of those renewal leases aren’t what Councilman Ydanis Rodriguez has in mind as he continues to promote the Small Business Jobs Survival Act, or SBJSA.

The SBJSA would require owners of all buildings, including co-ops, condominiums and small store buildings, to offer any current retail or commercial tenant a 10-year renewal lease.