A petite glass-fronted retail and office building is rising just south of Rockefeller Center, mid-block at 12 W. 48th St.

DNA Development drafted Ennead Architects — the former Polshek Partnership — to design a jewel box with an angled, all-glass façade to provide visibility from both Rockefeller Center and Fifth Avenue just steps away.

DNA’s Alex Sachs says the firm is targeting tenants that can use all 30,939 square feet for retail or use one or more of the upper floors for offices. “For a foreign brand, it’s a bite-sized opportunity to have offices and retail below,” he said. “You can plant your own flag and be in a branding location.”

Floor sizes start with the 20-foot-high, 7,286-square-foot ground floor, with 5,707 square feet on the second floor, which also has a 20-foot-tall ceiling and could include an outdoor patio, another 5,707 square feet on the third floor, and 4,714 square feet on the fourth. The roof can be made into a deck, and there is a 7,525-square-foot basement with a 15-foot-high ceiling.

Broker Kenji Ota of Cushman & Wakefield said the asking rent is at a “significant” discount to Rockefeller Center and Fifth Avenue spaces.

DNA bought the old seven-story garage from Gary Barnett’s Extell Development for $37.2 million a year ago and is about to put up the steel.

The firm is also about to start closing on its Brooklyn residential condo at 280 St. Marks Place and is working on the conversion of 350 W. 71st St. into another condo.