The Plaza Hotel is losing its celebrity-infused spa.

The Plaza’s current luxury spa operator, Caudalíe Vinotherapie Spa, is taking its A-list and moving to 819 Madison Ave., some 10 blocks north, in March, The Post has learned.

Sources said the spa will close its Plaza doors at the end of January.

Among its clients are Emma Roberts, Sigourney Weaver, Alexander Wang, Rachael Ray, Tyra Banks and designer Jason Wu, who even collaborated on a limited edition product: Jason Wu for Caudalíe Beauty Elixir.

The new, 10-year lease on Madison is for 1,620 square feet in a renovated townhouse — owned by Friedland Properties — that sits between East 68th and East 69th streets.

Eric Le Goff and Hillary Muss of Cushman & Wakefield represented Caudalíe in the transaction.

“We will have a new spa opening in the near future. However, we cannot confirm details at this point,” a Plaza spokeswoman said.