Rock is returning to Manhattan’s Music Row.

A new Hard Rock Hotel will rise on the West 48th Street strip between Avenue of the Americas and Seventh Avenue just off Times Square, which was once lined with music stores such as Manny’s Music and Rudy’s guitar shop.

The Post has learned the hospitality company has come to an agreement with Extell Development’s Gary Barnett to create a new music-themed hotel on his site, at 159 W. 48 St., where there currently sits a seven-story garage.

The permits are in place to begin demolition. The garage is within the special Times Square zoning district that allows the transfer of theater air rights on the site. None of the parties would comment.

Sam Ash had a shop in the base of the garage, which is across the street from the now-shuttered Manny’s. The garage is directly behind the office tower at 1221 Ave. of the Americas.

Since the 1930s, the block had been filled with stores where musicians like Eric Clapton, Jimi Hendrix and the Rolling Stones could hang out and buy instruments.

But one by one, they were shuttered for higher rents and higher towers.

The music died in 2015, when Alex Carozza’s accordion store moved off the block after 50 years.

As a music and celebrity magnet, the new Hard Rock Hotel aims to bring some of the old energy back to the street.

The now global restaurant, hotel, resort and casino chain was born as a café on West 57th Street. Ironically, it was forced to move after Barnett bought that building.