It’s bottoms up for the Heartland Brewery, which is closing its doors at 35 Union Square West on Jan. 1.

The mini-chain first began in 1994 when it subleased from an entity whose net lease on the entire building is expiring. The handful of market rate residential renters on the second, third and fourth floors have also been asked to leave.

The owners have hired Brandon Singer and Joanne Podell of Cushman & Wakefield to find a new tenant for either just the restaurant or for the entire building.

The restaurant has 4,000 square feet on the ground with an asking rent of $450 per foot, along with a 2,200-square-foot mezzanine that’s worth $125 a foot. A storage, prep and kitchen space in the basement is also 4,000 feet.

“We opened in 1994 and had a very nice run,” said Jon Bloostein, the proprieter of the chain and its flagship.

His rent started at $150,000 and has climbed. He would stay if he could afford the new asking rent that totals over $2 million a year. After fronting on Union Square Park, a smaller spot or one on a side street isn’t so appetizing to him.

While Bloostein said he is looking to grow his core brand, he’s also appealing to younger drinkers with geographically and historically relevant spaces like his new Houston Hall at 222 W. Houston and Flatiron Hall at 38 W. 26th St. in NoMad, where he says “nothing is new.”

“We’re opening a beer hall and beer garden — Port Chester Hall — at the Port Chester railroad station,” just a stone’s throw from the reinvigorated Capitol Theater, he said, adding, “People can take Metro North and not have to drive.”

SHAZAM, the music and TV sharing app, is expanding from executive suites in 230 Park Ave. to 9,275 square feet on the 19th floor of nearby 52 Vanderbilt Ave.

Evan Margolin, Lance Leighton and Gabe Marans of Studley represented Shazam, while Lloyd Desatnick and Jonathan Schifrin of Jones Lang LaSalle, represented the Brause family owners in the deal.

According to Melissa Brause Rackoff, the asking rent is in the low $50s a foot.

“We will build out their space that has high exposed ceilings and lots of light,” she said.

The building is between E. 44th and 45th streets opposite Grand Central. Tech firms AdLarge Media and SocialFlow recently leased floors in the building, according to David Brause, president of the family company.