In what will be a game changer for the neighborhood, Whole Foods has inked a deal to open in Harlem at 100 W. 125th St. on the southwest corner of Lenox Avenue.

The organic grocery chain also signed to open on the corner of 87th Street and Third Avenue.

In Harlem, the grocer will fill 39,000 square feet on the ground and lower levels of a new project being developed by retail maestro Jeff Sutton. The ground floor asking rent was $180 per square foot. The Post reported the deal on its website yesterday.

Burlington Coat Factory will open in 70,000 square feet on the top three floors, and we predicted in June the wholesome behemoth would also land there.

Jacqueline Klinger and Chase Welles of SCG Retail repped the food giant on both deals.

Sutton repped his Wharton Properties for his upcoming five-story building that will have the potential for a residence or hotel above.

Stay tuned for a mid-2015 opening.

The Third Avenue site was repped by Gary Alterman of RKF and will open in mid-2014.

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Rockpoint has signed a $280 million deal to buy an 80 percent stake in 1440 Broadway that will recapitalize the 25-story, 740,000 square-foot Times Square South building at about $350 million.

The investment company is replacing Prudential Real Estate in the deal. Partner Monday Properties manages and leases the building that houses Macy’s offices and digital marketing firm Razorfish, along with Liz Claiborne divisions Juicy Couture and Lucky Jeans.

Doug Harmon and Adam Spies of Eastdil Secured have been marketing the stake but did not return calls for comment.

The deal duo also marketed Blackstone’s 49.9 percent operating stake in 1411 Broadway, which it acquired when it bought Trizec Properties.

As we said in July, that is in contract to Canadian pension fund Ivanhoe Cambridge in a recap of the 1.2 million square-foot building at $735 million. The San Francisco-based Swig family will stay in the deal.

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Another Times Square South building fully occupied by fashion giant Donna Karan is being marketed by a team from Jones Lang LaSalle with the hope of fetching $70 million.

Sitt Asset Management and Ralph Tawil’s Centurion Realty have hired JLL’s “fearless foursome” — Richard Baxter, Ron Cohen, Scott Latham and Jon Caplan — to sell the 13-story building at 240 W. 40th St. between Seventh and Eighth avenues near the Times tower.

Donna Karan’s lease for the “highly improved space” in the 162,000 square-foot building goes through 2016.

There is a glass-enclosed penthouse. Several of the 10,000 square-foot floors spread into the adjacent building owned by others and are not included in this deal.

If the LVMH-owned company moves, Baxter said, a new owner could attract other tenants.

“All the tech companies and design companies are all gravitating to this neighborhood, and it is the last frontier of Lower Midtown rents,” he said.

A Dunkin’ Donuts, Popeye’s, Boi Noodles and the Guy & Gallard gourmet shop occupy the street retail.

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Real-estate scion Scott Resnick of SR Capital finally closed yesterday on his building in Chelsea, sources said.

Resnick spent $34 million for the tan- and red-brick former artist building at 551 W. 21st St. It is opposite Chelsea Piers on a large Eleventh Avenue corner lot with Hudson River views.

We hear he also closed on the 20,500 square feet of air rights from the adjacent Chelsea Art Museum on West 22nd Street. We told you about both pending deals last year.

Resnick did not return calls for comment, but we’re sure he has something magnificent up his sleeve for that corner. We’re hoping the project has plenty of terraces.

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C. Wonder will quickly open this week at 155 Fifth Ave. now that Ann Taylor has moved across the avenue to 156 Fifth.

C. Wonder will occupy 4,500 square feet on the ground and the same amount in the lower level of the former temple, with an asking rent of $400 per square foot.

Ann Taylor was there on a temporary basis while constructing its new store.

“We arranged for a temporary deal for C. Wonder for the holidays, and then afterwards they will close and then reopen in a newly built-out store in the spring,” said Joanne Podell of Cushman & Wakefield, who represented the building in the lease along with Brandon Singer.

As Podell normally reps C. Wonder, they brought in Mark Masinter of Open Realty in Dallas to rep the retailer in this transaction.

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