In what will be a game-changer for the neighborhood, Whole Foods has finally inked a deal to open in Harlem at 100 W. 125th St. on the southwest corner of Lenox Avenue.

The organic grocery chain will occupy about 39,000 square feet on the ground and lower levels of a new project that is being developed by retail maestro Jeff Sutton. The ground floor asking rent is over $180 per foot.

The Post reported in June that Burlington Coat Factory had signed a lease for 70,000 square feet for the top three floors and predicted that Whole Foods would also land there.

Jacqueline Klinger and Chase Welles of SCG Retail repped the food giant in the lease at the now under construction five-story building that will have the potential for a residence or hotel above.

Another market will also open in a 38,000-square-foot space at the corner of 87th Street and Third Avenue in 2014.