The slender Bush Tower at 130 W. 42nd St. is on the market and potential buyers are hoping that this time the owners agree to make a deal.

The 260,000-square-foot midblock building with another entrance on W. 41st Street was last offered in 2006, but pricing never reached the lofty $165 million expectations.

Now, with the area getting a facelift, first-round bids due Oct. 26 are expected to fetch in the $140 million range.

“It’s a great value and added opportunity in a location that is changing dramatically,” said Cushman & Wakefield’s Nat Rockett, who was also the previous broker while with another firm.

This time, Rockett and C&W colleagues Helen Hwang and Karen Wiedenmann are working on the offering for American Properties.

Since 40 percent of the leases roll in the next three years, Rockett said, “You can get to the mark-to-market opportunity pretty quickly.”

To the west, a hotel is rising on a formerly vacant lot next to the Knickerbocker Hotel that is also getting a new life.

To the east, as The Post’s Steve Cuozzo first reported, Blackstone is dismantling low-rise structures to put up a glass retail pavilion.